||Associations of family histories of diabetes mellitus and hypertension with the occurrence of gestational diabetes mellitus, gestational hyper tension, and preeclampsia：multivariate analysis.
Shiho , Nagayama ,
Kayo , Takahashi ,
Akihide , Ohkuchi ,
Chikako , Hirashima ,
Miyuki , Arai ,
Hirotada , SuzukiShigeki , Matsubara
自治医科大学紀要 = Jichi Medical University Journal
7 , 2017-03 , 自治医科大学
Objective： We herein determined whether family histories of hypertension （HT） and diabetes mellitus（DM） were independent risk factors for gestational hypertension （GH）, preeclampsia （PE） andgestational diabetes mellitus（ GDM）.Methods：A prospective cohort study was conducted using 1,737 pregnant women. We evaluated fivefactors：a family history of HT （father, mother, or both）, a family history of DM, age ≥40 years old,obesity, and high blood pressure （mean blood pressure level ≥90 mmHg at 16-19 gestational weeks）,and three outcomes：GH, PE, and GDM. Univariate and multivariate logistic regression analyses wereperformed.Results：High blood pressure was an independent risk factor for the occurrence of PE （OR ［95% CI］：4.6［ 2.3-9.2］）, pre-pregnancy obesity was an independent risk factor for the occurrence of GH（ 4.4［ 1.3-15］）, whereas a family history of HT or DM was not an independent risk factor for either PE or GH .Independent risk factors for the occurrence of GDM were a family history of DM（ 5.5［ 3.3-9.1］）, age ≥40years old（ 2.2［ 1.1-4.1］）, and pre-pregnancy obesity（ 4.2［ 2.5-6.9］）.Conclusions：After adjusting for other factors, a family history of DM was not associated with theoccurrence of either PE or GH. In addition, a family history of HT was not an independent risk factor forGDM.