Departmental Bulletin Paper Clinical features of seven Japanese patients with anti-PL-12 antibody: frequent positivity for anti-cyclic citrullinated peptide antibody

Yoichiro, Akiyama  ,  Takao, Nagashima  ,  Masahiro, Iwamoto  ,  Seiji, Minota

We report the clinical features of 7 Japanese patients with anti-PL-12 antibody. Rheumatoid arthritis( RA)was the most common diagnosis (4/7 patients). Interstitial lung disease (ILD) was detected in all 7 patients,polyarthritis was present in 5 patients, and elevation of creatine kinase was noted in 2 patients. The 4 patients with RA were all positive for anti-cyclic citrullinated peptide( CCP) antibody, and the titer was high in 3 of them. Bone erosions were detected in 3 patients. One patient developed rapidly progressive ILD. In conclusion, a high frequency of anti-CCP-positive RA was detected among Japanese patients with anti-PL-12 antibody.

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