||Clinical features of seven Japanese patients with anti-PL-12 antibody： frequent positivity for anti-cyclic citrullinated peptide antibody
Yoichiro, Akiyama ,
Takao, Nagashima ,
Masahiro, IwamotoSeiji, Minota
自治医科大学紀要 = Jichi Medical University Journal
45 , 2016-03 , 自治医科大学
We report the clinical features of 7 Japanese patients with anti-PL-12 antibody. Rheumatoid arthritis（ RA）was the most common diagnosis （4/7 patients）. Interstitial lung disease （ILD） was detected in all 7 patients,polyarthritis was present in 5 patients, and elevation of creatine kinase was noted in 2 patients. The 4 patients with RA were all positive for anti-cyclic citrullinated peptide（ CCP） antibody, and the titer was high in 3 of them. Bone erosions were detected in 3 patients. One patient developed rapidly progressive ILD. In conclusion, a high frequency of anti-CCP-positive RA was detected among Japanese patients with anti-PL-12 antibody.