Alleviation of the Drunken Frenzy/Hangover-like Symptoms by SJS, a Japanese Herbal Medicine, in MiceAlleviation of the Drunken Frenzy/Hangover-like Symptoms by SJS, a Japanese Herbal Medicine, in Mice マウスの悪酔い／二日酔い様症状に及ぼす生薬製剤SJSの改善効果
A Japanese herbal medicine SJS is made of hot water extract of Chishimazasa leaves (Sasa kurilensis (Ruprecht) Makino et Shibata: SS), and ethanol extracts of Japanese red pine leaves (Pinus densiflora Siebold & Zucc.: RP) and Ginseng roots (Panax ginseng C.A. Meyer: PG). The aim of this study was to assess the modification by SJS of the intoxication and drunken frenzy models in terms of discrete shuttle avoidance behavior in mice. The response rate (number of shuttles) was increased by ethanol (2 g/kg p.o.), but decreased by the combined administration of ethanol + Ca-cyanamide (10 mg/kg p.o.), an anti-alcoholic drug. Although SJS, freely given 10% solution for 4 weeks and longer, or acutely administered at doses of 10 and 20 ml/kg p.o., did not change the ethanol effect, it significantly recovered the decreased response rate by ethanol + Ca-cyanamide. A similar significant recovery of response rate was demonstrated by PR and SS, but not by PG. These results suggest that SJS alleviates the ethanol-induced drunken frenzy and/or hangover without significant effect on the ethanol intoxication (disinhibition).