A study of girls with PMLD in the special school:a possible involvement of estrogen-induced release of serotonin in the subfornical organA study of girls with PMLD in the special school:a possible involvement of estrogen-induced release of serotonin in the subfornical organAA12124651
95 , 2018-02-15 , 鳴門教育大学 , Naruto University of Education
Children with Profound and Multiple Learning Difficulties/Disabilities (PMLD) belong to special schools dealing with physical difficulties in Japan and almost of them have cerebral palsy. Typical symptoms are spasticity, epilepsy, mental retardation, learning disabilities and ataxia. Sometimes they have a strong behavioral disorder (Bellamy et al, 2010). In this study, we attempt to speculate that the 5-HT release from the SFO may participate in the cases of behavioral disorders of three PMLD girls who belong to a special school. Our speculation also may offer to explain the relationship between their behavioral disorders and changes in plasma 5-HT and/or estrogen. From the three cases and previous findings lead to the hypothesis that the levels of 5-HT levels regulating by estrogen in the PMLD children brains may be implicated in the any disorder. In addition, our speculations imply that it may necessary to measure regularly the either plasma 5-HT or estrogen levels in the PMLD children for controlling a wrong behavior.