Departmental Bulletin Paper 海馬神経細胞新生の機能的意義
The functional significance of the hippocampal neurogenesis

花田, 安弘

Adult neurogenesis has been demonstrated in two sites of the brain, the olfactory bulb and the hippocampaldentate gyrus. The hippocampal dentate gyrus has been involved in pattern separation, the functionof distinguishing similar stimuli, and in learning and memory processes. On the other hand, there has been accumulating data which demonstrate the involvement of dentate neurogenesis in the effects of antidepressant.The differences between the dorsal and ventral hippocampus have been demonstrated in the projection sites and the effects of lesion on behavior. The function of learning and the function of anxiety and depress are considered to be implemented by the dorsal hippocampus and the ventral hippocampus, respectively. Deficit in dentate neurogenesis is considered to be related to spatial learning deficits in the dorsal hippocampus, and to discrimination deficits between anxious stimulus and safe stimulus or decrease in the effects of antidepressant in the ventral hippocampus.

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