Journal Article Intracranial hemorrhage and platelet transfusion after administration of anti-platelets agents: Fukushima Prefecture

Suzuki, Yuhko  ,  Sato, Taku  ,  Sakuma, Jun  ,  Ichikawa, Masahiro  ,  Kishida, Yugo  ,  Oda, Keiko  ,  Watanabe, Yoichi  ,  Goto, Takeshi  ,  Sato, Masahiro  ,  Nollet, Kenneth E  ,  Saito, Kiyoshi  ,  Ohto, Hitoshi

62 ( 1 )  , pp.51 - 56 , 2016 , The Fukushima Society of Medical Science
We conducted a case series study to assess intracerebral hemorrhage (ICH) in the context of anti-platelets agents (APAs) and platelet (PLT) transfusion in Fukushima Prefecture.This study included patients who were newly diagnosed with ICH between January 2008 and June 2014 in the neurosurgical hospitals of Fukushima Prefecture. Four of ten neurosurgical hospitals responded to our questionnaire. Of 287 ICH patients, 51 (20.6%) were on APA therapy, of whom PLT transfusion was given to only one persistently bleeding patient who was on dual anti-platelet therapy. In a follow-up survey, 30 out of 51 ICH patients on APA therapy, average age 75 years, were analyzed, of whom 21 (70%) were male. The predominant underlying disease was diabetes mellitus. It is interesting to note that peripheral artery disease and aortic aneurysm were among the indications for APAs. ICH was mainly observed supratentorially. Hematoma enlargement was observed in 13 (44.8%) cases. By day 7, 3 patients (10%) had died from complications of ICH. In this study, we show that ICH during APA therapy matched what was observed in Kanagawa Prefecture. Whether or not a national survey differs, we anticipate greater statistical validity and an opportunity to improve patient outcomes in Japan and around the world.

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