学術雑誌論文 The non-canonical role of Aurora-A in DNA replication

Tsunematsu, Takaaki  ,  Arakaki, Rieko  ,  Yamada, Akiko  ,  Ishimaru, Naozumi  ,  Kudo, Yasusei

5p.Article187 , 2015-08-25 , Frontiers Media S.A.
ISSN:2234943X
内容記述
Aurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role. During mitosis, Aurora-A protein is stabilized by its phosphorylation at Ser51 via blocking anaphase-promoting complex/cyclosome-mediated proteolysis. Importantly, overexpression and/or hyperactivation of Aurora-A is involved in tumorigenesis via aneuploidy and genomic instability. Recently, the novel function of Aurora-A for DNA replication has been revealed. In mammalian cells, DNA replication is strictly regulated for preventing over-replication. Pre-replication complex (pre-RC) formation is required for DNA replication as an initiation step occurring at the origin of replication. The timing of pre-RC formation depends on the protein level of geminin, which is controlled by the ubiquitin–proteasome pathway. Aurora-A phosphorylates geminin to prevent its ubiquitin-mediated proteolysis at the mitotic phase to ensure proper pre-RC formation and ensuing DNA replication. In this review, we introduce the novel non-canonical role of Aurora-A in DNA replication.
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http://repo.lib.tokushima-u.ac.jp/files/public/11/110980/20171225133037766437/fonc_5_187.pdf

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