学術雑誌論文 原発性甲状腺癌の年令による臨床病理学的特徴および予後の比較検討
The impact of age on clinicopathologic features and prognosis of primary thyroid cancer
ゲンパツセイ コウジョウセンガン ノ ネンレイ ニヨル リンショウ ビョウリガクテキ トクチョウ オヨビ ヨゴ ノ ヒカク ケントウ

紺谷, 桂一  ,  森下, 敦司  ,  久保, 尊子  ,  橋本, 新一郎  ,  村澤, 千沙  ,  法村, 尚子  ,  橋本, 希  ,  監崎, 孝一郎  ,  環, 正文  ,  三浦, 一真  ,  横見瀬, 裕保

73 ( 1-2 )  , pp.59 - 64 , 2017-04-25 , 徳島医学会
ISSN:00373699
NII書誌ID(NCID):AN00102041
内容記述
Two-hundred thirty-six patients with primary thyroid cancer who received operation were divided into two groups by age, i.e.,59patients of age <45years(Early adulthood, EA)and177 patients of age≧45years(advanced age, AA). Clinicopathologic factors and disease-free survival (DFS)were compared between the two groups. There was no difference in clinicopathologic factors except for higher proportion of patients with poorly differentiated adenocarcinoma in the AA patients than in the EA patients(6.7% vs. 0%, p=0.041). DFS was significantly longer in the AA patients than in the EA patients(disease-free rates at10years after operation,94.8% vs. 72.5%, p=0.0031). Overall survival was not different between the two groups. The EA patients who showed shorten DFS were divided into two groups,17 patients of age <30 years (juvenile and young adult, JYA)and 42 patients of age ≧30 years, and DFS of each group was compared with that of the AA patients. Although disease-free survival rates at 10 years of the JYA patients were not different(92.6% vs.94.8%, p=0.125), those of patients of age ≧30years were significantly lower than those of the AA patients(70.0% vs. 94.8%, p=0.0021). These findings suggest that patients with primary thyroid cancer who are ≧30 years old in the young adulthood should be observed carefully after operation for early detection of relapse.
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http://repo.lib.tokushima-u.ac.jp/files/public/11/110416/20171114103558668971/sam_73_1-2_59.pdf

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