Journal Article 炎症環境による歯髄細胞の幹細胞化 : 歯髄細胞分化に与える腫瘍壊死因子( TNF-α) の影響
Reprogramming of Human Dental Pulp Cells Mediated by Inflammatory Signals : Effects of TNF-α on Human Dental Pulp Cell Differentiation
エンショウ カンキョウ ニヨル シズイ サイボウ ノ カンサイボウカ : シズイ サイボウ ブンカ ニ アタエル シュヨウ エシ インシ TNF-α ノ エイキョウ

上枝, 麻友

28 ( 1 )  , pp.1 - 7 , 2015-07-10 , 四国歯学会
During normal pulp tissue healing, inflammatory cytokines, such as tumor necrosis factoralpha (TNF-α) or interleukins, act in the initial 48 hours (inflammatory phase) and play important roles not only as chemo-attractants of inflammatory cells and stem/progenitor cells but also in inducing a cascade of reactions toward tissue regeneration or reparative dentin formation or both. Previous reports have shown that inflammatory cytokines regulate the differentiation capacity of dental pulp stem/progenitor cells (DPCs), but none has interrogated the impact of these cytokines on the stem cell phenotype of stem/progenitor cells.In this review, I would like to summarize about the effects of a short-term treatment with TNF-α on the stem cell phenotype and differentiation ability of human DPCs.

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