Journal Article Feasibility of arterial sclerosis prediction using computational fluid dynamics analysis: Findings from a basal simulation study


Wall shear stress (WSS) acts on arterial vessel walls, and it can be used to evaluate the cause of arteriosclerosis through quantitative computational fluid dynamics (CFD) and by measuring blood components such as very low density lipoprotein. This study aimed to quantify the WSS and the oscillatory shear index (OSI) in the vascular system. We also aimed to elucidate the types of hemodynamics that are specific risk factors for arteriosclerotic disease and the effects of configurations of the bifurcation angle and carotid bulb in a simulation study. The bifurcation area on the ICA side had low WSS at both systolic and diastolic cardiac phases. The WSS was low at < 30 Pa when the bifurcation angle was < 45° and OSI was high in a carotid bulb with a diameter of 14 mm in the bifurcation area. This area of low WSS reflects the site where carotid stenosis originates. The probability of carotid stenosis could be estimated in regions with specific hemodynamics using CFD analysis.
動脈硬化の原因は,低比重リポ蛋白などの血中成分だけでなく,現在は動脈の血管壁に作用する壁面せん断応力(Wall shear stress: WSS)が関係し,WSS は数値流体力学(Computational fluid dynamics: CFD)解析によって評価が可能である。本研究の目的は,血管内壁のWSS を定量的に評価し,動脈硬化性疾患のリスク因子である特異的な血流動態と血管形状の幾何学的形状(分岐角度,球部径)との関連を明らかにすることである。総頸動脈の内頸動脈の分岐部は,低い壁面せん断応力が生じ,心臓の収縮期及び拡張期も同様の結果を示した。この部位は頸動脈狭窄が生じる部位で,血管形状の幾何学的形状に大きく影響し低いWSS が大きく関与した。頸動脈狭窄症の予測はCFD 解析を用いることで特異的な血流動態及び幾何学的領域で推定することが可能である。

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