Departmental Bulletin Paper Spontaneously Hypertensive Rat, Stroke-prone Spontaneously Hypertensive Rat 及びWistar Kyoto Rat の24時間血圧概日リズムの基礎的検討
Twenty-four-hour blood pressure in Spontaneously Hypertensive rats, Stroke-prone Spontaneously Hypertensive rats, and Wistar Kyoto rats

根岸, 裕子  ,  川上, 浩平  ,  Hiroko, Negishi  ,  Kohei, Kawakami

64pp.1 - 5 , 2017-03-31
Twenty-four-hour ambulatory blood pressure monitoring has focused on the incidence of hypertension-related end organ damage. This study analyzed 24-hour blood pressure in normotensive Wistar Kyoto rats(WKY), spontaneously hypertensive rats( SHR), and stroke-prone SHR( SHRSP), which are used as a model of hypertension. Each rat at 12 weeks of age was used for 24-hour blood pressure monitoring for 7 days. This ambulatory blood pressure monitoring was conducted using a telemetry system. Twenty -four-hour systolic and diastolic blood pressures in SHRSP( n=5) were significantly higher than in SHR( n=5) and WKY( n=5), but the heart rate did not change among these strains. SHRSP showed the non-dipper phenomenon for 2 days. From these results, the circadian rhythm in 24-hour ambulatory blood pressure of SHRSP was different from those in SHR and WKY, possibly due to marked hypertension.

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