||Spontaneously Hypertensive Rat, Stroke-prone Spontaneously Hypertensive Rat 及びWistar Kyoto Rat の24時間血圧概日リズムの基礎的検討
Twenty-four-hour blood pressure in Spontaneously Hypertensive rats, Stroke-prone Spontaneously Hypertensive rats, and Wistar Kyoto rats
根岸, 裕子 ,
川上, 浩平 ,
Hiroko, NegishiKohei, Kawakami
5 , 2017-03-31
Twenty-four-hour ambulatory blood pressure monitoring has focused on the incidence of hypertension-related end organ damage. This study analyzed 24-hour blood pressure in normotensive Wistar Kyoto rats（WKY）, spontaneously hypertensive rats（ SHR）, and stroke-prone SHR（ SHRSP）, which are used as a model of hypertension. Each rat at 12 weeks of age was used for 24-hour blood pressure monitoring for 7 days. This ambulatory blood pressure monitoring was conducted using a telemetry system. Twenty -four-hour systolic and diastolic blood pressures in SHRSP（ n=5） were significantly higher than in SHR（ n=5） and WKY（ n=5）, but the heart rate did not change among these strains. SHRSP showed the non-dipper phenomenon for 2 days. From these results, the circadian rhythm in 24-hour ambulatory blood pressure of SHRSP was different from those in SHR and WKY, possibly due to marked hypertension.