Departmental Bulletin Paper Schizencephaly and Porencephaly Due to Fetal Intracranial Hemorrhage: A Report of Two Cases

Harada, Takashi  ,  Uegaki, Takashi  ,  Arata, Kazuya  ,  Tsunetou, Takako  ,  Taniguchi, Fuminori  ,  Harada, Tasuku

60 ( 4 )  , pp.241 - 245 , 2018-02-05 , Tottori University Faculty of Medicine
ISSN:0513-5710
NCID:AA00892882
Description
Schizencephaly and porencephaly are extremely rare types of cortical dysplasia. Case 1: Prenatal magnetic resonance imaging (MRI) showed wide clefts in the frontal and parietal lobes bilaterally. On postnatal day 3, MRI T2-weighted images showed multiple hypointensities in the clefts and ventricular walls, suggestive of hemosiderosis secondary to intracranial hemorrhage. Case 2: Prenatal MRI showed bilateral cleft and cyst formation in the fetal cerebrum, as well as calcification and hemosiderosis indicative of past hemorrhage. T2-weighted images showed hypointensities in the same regions as the calcification, corresponding with hemosiderosis due to intracranial hemorrhage on postnatal day 10. Thus, prenatal MRI was useful for diagnosing schizencephaly and porencephaly. Schizencephaly and porencephaly were thought to be due to fetal intracranial hemorrhage, which, in the porencephaly case, may have been related to a mutation of COL4A1.
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