紀要論文 Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas

Matsushita, Michiko  ,  Iwasaki, Takeshi  ,  Nonaka, Daisuke  ,  Kuwamoto, Satoshi  ,  Nagata, Keiko  ,  Kato, Masako  ,  Kitamura, Yukisato  ,  Hayashi, Kazuhiko

60 ( 3 )  , pp.145 - 153 , 2017-09-15 , Tottori University Faculty of Medicine
ISSN:0513-5710
NII書誌ID(NCID):AA00892882
内容記述
[Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV).[Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs.[Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients.[Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones.
本文を読む

http://repository.lib.tottori-u.ac.jp/Repository/file/5480/20170920145545/yam60%283%29_145.pdf

このアイテムのアクセス数:  回

その他の情報