Departmental Bulletin Paper ヒスチジンを中心とした塩基性アミノ酸を配位子とするポリマー性銀(I)錯体の合成、 構造解析及び抗菌活性
Synthesis, Structure and Antimicrobial Activity of Silver(I) Coordination Polymers with Histidine and Other Basic Amino Acid Ligands

力石, 紀子  ,  Chikaraishi Kasuga, Noriko  ,  野宮, 健司  ,  Nomiya, Kenji  ,  松永, 諭  ,  Matsunaga, Satoshi  ,  両角, 宗一郎  ,  Morozumi, Soichiro  ,  高山, 晃彦  ,  Takayama, Akihiko  ,  高木, 由貴  ,  Takagi, Yoshitaka  ,  井上, ちさと  ,  Inoue, Chisato  ,  柳田, 貢助  ,  Yanagita, Kousuke  ,  吉川, 理絵  ,  Yoshikawa, Rie

26pp.47 - 52 , 2015-06-30 , 神奈川大学総合理学研究所
The coordination environment of Ag+, i.e., not only the atom coordinated with the silver(I) ion, but also the structure around the silver(I) ion and the ease of ligand replacement, plays an important role in the antimicrobial activities of silver(I) complexes. Water –soluble neutral and anionic silver(I) complexes with histidine (D-1, L-1 and L-4) and water-insoluble ones (D-2, L-2 and DL-3) were prepared depending on the reaction conditions, including the reaction time and pH. They exhibited a wide spectrum of effective antimicrobial activities against both Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacteria as well as yeasts (Candida albicans and Saccharomyces cerevisiae). Various structures of silver(I) complexes with basic amino acids suggest that histidine as well as arginine and lysine residues can uptake silver(I) ion in peptides and proteins and transfer metal ions outside the cell depending on local proton concentrations in the cell.
原著2014 年度神奈川大学総合理学研究所共同研究助成論文

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