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Comparative evaluation of the physicochemical properties of acetaminophen formulationsComparative evaluation of the physicochemical properties of acetaminophen formulations |
"/井上, 裕/"井上, 裕 ,
"/鈴木, 健吾/"鈴木, 健吾 ,
"/池田, 貴司/"池田, 貴司 ,
"/角田, 結菜/"角田, 結菜 ,
"/Onoda, Takahiro/"Onoda, Takahiro ,
"/菅原, 光希/"菅原, 光希 ,
"/土屋, 侑瑛/"土屋, 侑瑛 ,
"/釣, みずき/"釣, みずき ,
"/惠沢, 敏成/"惠沢, 敏成 ,
"/金本, 郁男/"金本, 郁男
3
(
6
)
, pp.1031
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1038 , 2015-06 , Atom and Cell Publishers
ISSN:2321331023213086
Description
The current study compared the physicochemical properties of 7 Acetaminophen (AAP) formulations from Thailand (3 formulations), the Philippines (3 formulations), and Japan (1 formulation). This study assessed the appearance of formulations from Thailand (T-A, -B, and -C), the Philippines (P-A, -B, and -C), and Japan (J). This study was subjected to a hardness test, uniformity of weight test, content uniformity test, and dissolution test in accordance with the Japanese Pharmacopoeia. Results of the hardness test indicated that all of the formulations had a hardness of 70 N or greater. All formulations showed within 97-02% by uniformity of weight test. Comparison of dissolution profiles indicated that the P-B formulation had dissolution of about 77% at 15 min, and this level of elution was lower than that from other formulations (p<0.05). Unlike the P-B formulation, the other 6 formulations had around 85% or more elution of AAP in 15 min. The physical and chemical properties of the T-A, -B and -C formulations that are used in the Thailand, the P-A and -C formulations that are used in the Philippines, and the J formulation that is used in Japan complied with the Japanese Pharmacopoeia. Thus, these formulations are assumed to be equivalent.
Open Access Journal
Full-Text
http://libir.josai.ac.jp/il/user_contents/02/G0000284repository/pdf/JOS-2321-3086_3_1031.pdf