Departmental Bulletin Paper 腸内微生物叢を介した食物アレルギー制御の可能性について ~食物アレルギーに対する食事療法の確立にむけて~
Regulation of Food Allergy via Microbiota

野村, 卓正  ,  千葉, 歩美  ,  Nomura, Takamasa  ,  Chiba, Ayumi

7pp.29 - 46 , 2016-03-31 , 仁愛大学
Food allergy is a pathological condition in which the immune system's tolerance of food antigens is disordered. In peripheral tissues, regulatory T cells are an important T cell subset for inducing immune tolerance to food allergens. The groups of commensal bacteria Clostridium cluster IV and XIVa are identified as an inducer of regulatory T cells in the gut. It was also clarified that butyric acid, one of metabolites from these bacteria, is an inducer of regulatory T cells. These findings suggest that butyric acid produced by these bacteria is an important metabolite for regulation of gut immune systems and food allergy. However, it was unclear what dietary nutrients are substrates for fermentation of these bacteria in order to produce butyric acid. In this paper, an outline is given of current findings for microbiota and metabolites, gut mucosal immunity, dietary fibers and oligosaccharides, and the prebiotic effect of dietary fibers on the regulation of allergy is reviewed.

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