Departmental Bulletin Paper 乳房Paget病の6例

冨田, 香  ,  河合, 由紀  ,  森, 毅  ,  久保田, 良浩  ,  梅田, 朋子  ,  阿部, 元  ,  石田, 光明  ,  岡部, 英俊  ,  谷, 眞至

28 ( 1 )  , pp.29 - 33 , 2015-03-17 , 滋賀医科大学雑誌編集委員会
Paget’s disease of the breast shows eczematous changes of the nipple-areolar complex, and characteristichistopathological feature of this condition is the presence of Paget’s cell in the keratinizing epithelium of the nipple, whichhas large and pale cytoplasm and round or oval shape with large nuclei and prominent nucleoli. Paget’s disease of the breastis limited to non-invasive or micro-invasive, and has a favorable prognosis. Paget’s disease with invasive lesions isclassified as Pagetoid cancer. We report six cases of Paget’s disease of the breast. Four cases were performed mastectomyand two cases were performed breast-conserving surgery. Four cases were performed sentinel lymph node biopsy. Skinbiopsy and cytology, and Magnetic resonance imaging (MRI) were useful for the diagnosis of Paget’s disease. In particular,MRI detected the extent of intraductal lesions and identified otherwise disease. MRI for patients with Paget’s disease wasuseful to distinguish it from Pagetoid cancer and determine the extent of surgical treatment.

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