Journal Article The epidemiological survey for atovaquone resistant related gene of Babesia gibsoni in Japan

Iguchi, Aiko  ,  Soma, Takehisa  ,  Suzuki, Hiroshi  ,  Xuan, Xuenan

78 ( 3 )  , pp.489 - 491 , 2016-03 , Japanese Society of Veterinary Science
Description
In 73 gDNA samples from Babesia gibsoni-infected dogs, the M121I variant population was measured by using allele-specific real-time PCR. Although the mechanism of atovaquone against B. gibsoni has not been clearly identified, it is reported that the mitochondria cytochrome b gene of the atovaquone-resistant B. gibsoni had a single-nucleotide substitution at nt363 (G to T), which resulted in the substitution of methionine with isoleucine (M121I). In this study, 3/73 samples showed over 5% M121I variant population. Although the M121I variant population is a low percentage, it runs the risk of spreading drug-resistant parasites. It is important to prevent the spread of drug-resistance, so we need to gather information about this at regular intervals.
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http://ir.obihiro.ac.jp/dspace/bitstream/10322/4421/1/78_15-0480.pdf

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