Synthesis of stimuli-responsive medical gel--Research works accomplished by using materials analysis facilities: XXVIII(4)--
棟近 歩斎藤 貴
29 , 2018-03-20 , 神奈川工科大学
Generally, antifebrile is used when human has fever caused to have cold. However, side effects such as a feeling of vomiting or dizziness may be caused when antifebrile was used excessively. Therefore, a method to control a released quantity by human body temperature is required. A gel which swells and shrinks based on differential temperature in the environment was focused for applying it to medical materials. A gel consist of polyrotaxane which is topological materials is easy to swell or shrink. Synthesis of stimuli-responsive polyrotaxane gel was performed in this study. And then, the shrinkage ratios of the obtained gel in temperature range of from 10 to 70℃ were evaluated. Temperature domain where mass of synthesized gel suddenly changed was 30 to 40℃. Mass of the gel decreased to 15% of original mass at high temperature. Mass of polyrotaxane gel decreased more than approximately 20% in comparison with usual stimuli-responsive gel.