学術雑誌論文 Acupuncture modulates functional connectivity of the brain: generating a small-world network in swallowing-related areas

赤間, 啓之  ,  akama, hiroyuki

14 ( no. 1 )  , pp.1 - 7 , 2018-04 , The Japan Society of Acupuncture and Moxibustion
内容記述
[Introduction] Functional connectivity of the brain can be modulated by interventional stimuli and serve as an indicatorof brain plasticity. Acupuncture has been argued to play an important role in the modification of neural circuits.Our objective was to elucidate the neural underpinnings of the effects of acupuncture on the act of swallowing.[Methods] We carried out a resting-state functional connectivity analysis by replicating an acupuncture manipulationreported in a prior study wherein treatment of patients with dysphagia led to remission of swallowing difficulties byshortening latency times. We inserted needles into KI3 and ST36 in the bilateral legs of each healthy volunteer, whounderwent this manipulation prior to the first and after the second resting-state functional magnetic resonance imagingsession.[Results] Indices such as local efficiency and the clustering coefficient were significantly altered in some subcorticaland cortico-subcortical areas. These indices moved toward what is called the "small world" in graph theory. Thenetwork vertices of interest were parts of swallowing-related, somatosensory, pain-specific, and acupuncture-relatedareas (specifically, left inferior frontal gyrus, left accumbens, and right cerebellum ).[Conclusion] Although the therapeutic value and neural effects of acupuncture are still under investigation, our studymay shed light on the neural underpinnings of the effects of acupuncture on the act of swallowing.

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