Journal Article Synthesis of 2-Indolyltetrahydroquinolines by Zinc (II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles

李, 廣哲  ,  Li, Guangzhe  ,  中村, 浩之  ,  Nakamura, Hiroyuki

An intramolecular hydroarylation-redox-cross dehydrogenative coupling (CDC) of propargylic anilineswith indoles proceeded in the presence of zinc(II) catalysts to give 2-indolyltetrahydroquinolines in good to high yields. Three C-H bonds (two sp2 and one sp3) are activated in one shot and these hydrogen atoms are trapped by a propargylic triple bond in the molecule.

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