Departmental Bulletin Paper 〈Case Reports〉Growth hormone deficiency associated with short stature in a very low birth weight infant after treatment for suspected intracranial cavernous hemangioma

Wada, Norihisa  ,  Minakata, Shunsuke  ,  Konishi, Yuhei  ,  Inoue, Tomohiro  ,  Okada, Mitsuru  ,  Takemura, Tsukasa

[Abstract] A female infant born at 30 weeks of gestation and weighing 1,276g developed a suspected intracranial cavernous hemangioma invading the sella turcica at the age of one month. She received high-dose steroid treatment with 5mg/ kg/ d of prednisolone, resulting in a reduction in the size of the hemangioma, and follow-up care began after discharge. At the age of six, it was noted that the girl’s growth in height was insufficient. Head magnetic resonance imaging (MRI) showed pituitary atrophy, and the results of a loading test led to a diagnosis of growth hormone deficiency resulting in a short stature. However, the administration of growth hormone brought her height up to the average by the age of 11.The patient’s intracranial lesion during the newborn period, which was suspected to be a cavernous hemangioma, may have contributed to her pituitary atrophy. The findings of this case suggest that infants who develop a space-occupying lesion in the sella turcica must be kept under long-term observation in view of the possible occurrence of a defective pituitary function.

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