Departmental Bulletin Paper 〈Originals〉Mammographic breast density change following postoperative adjuvant therapy in hormone receptor-positive breast cancer patients

Kubota, Michiyo  ,  Hamada, Mika  ,  Shinzaki, Wataru  ,  Azumi, Tatsuya  ,  Hashimoto, Yukihiko  ,  Inui, Hiroki  ,  Houjyou, Toshiya  ,  Fujishima, Makoto  ,  Komoike, Yoshifumi

<Abstract>Several studies have been reported that postoperative adjuvant endocrine therapy decreases mammographic breast density and that breast density change may be a prognostic factor for recurrence, however there are few studies on relationship between postoperative adjuvant therapy and breast density in Japan. We investigated changes in the breast density following postoperative adjuvant therapy in hormone receptor (HR)-positive breast cancer and whether breast density change is related to recurrence. We analyzed data from 240 HRpositive breast cancer patients who underwent surgery and received postoperative adjuvant therapy at our institution. The breast density was measured by contralateral breast mammography (MMG) using the Breast Imaging Reporting and Data System (the BI-RADS) classification, and breast density reduction was defined as the reduction of the BI-RADS density score on follow-up MMG compared with the pretreatment value. The breast density was reduced in 22 (9.2%) patients. Of patients with breast density reduction, 19 (86.4%) received a selective estrogen receptor modulator (SERM), and these patients showed significantly higher rates of breast density reduction compared with those receiving an aromatase inhibitor (AI ; p< 0.001). The addition of chemotherapy was not associated with the breast density reduction. Fifteen (6.1%) patients had recurrent disease. There was no patient with breast density reduction showed recurrence, however no significant correlation between breast density reduction and recurrence. In this study, the breast density reduction in adjuvant therapy of Japanese HRpositive breast cancer patients did not become a predictor of recurrence.

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