Journal Article Behavioral Adaptogenic Humoral Glycolipid in Mouse Given Various Stresses

Masuda, Yutaka

44 ( 2 )  , pp.69 - 72 , 2017-11-30 , 秋田医学会
Stresses spoil adaptation. Animals prepare behavioral adaptogenic substances for escaping from stressful situation. Mice given forced swimming stress prepared GalNAcα1-3GalNAc-lipid inducing hyperactivity, in the humoral lipoid fraction eluted with 150 mMNaCl. Mice given various stresses may differently prepare the behavioral adaptogenic glycolipid. Disadaptation induces depression. Depression closely relates to adrenergic and serotonergic neuronal activities. The glycolipid may be produced via these neuronal activities. Mice were twice given immunization stress, given forced swimming stress or given stress restricting the mobility on a raised platform, or not given the stresses as a control. Mice were also treated with a serotonin reuptake inhibitor clomipramine or a noradrenaline reuptake inhibitor maprotiline. Reactivity of the glycolipid was increased in mice given the forced swimming stress, and in mice given the immunization stress. The reactivity was also found in mice not given the stresses, but was decreased in mice given the mobility restriction stress. Treatment of the noradrenaline reuptake inhibitor dosedependently increased the reactivity, however, treatment of the serotonin reuptake inhibitor did not affect the reactivity. These suggest that the behavioral adaptogenic humoral glycolipid was prepared corresponding to the mobility, via not serotonergic but adrenergic neuronal activity.

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