Stresses induce disaptation. Disadaptation induces depression and death. Animals prepare internal stress-coping substances for keeping their adaptation. Mouse given forced swimming stress produced an adaptogenic substance, in humoral lipoid fraction eluted with 100 mM NaCl, for keeping the physical strength, and mouse given repeated immunization stress prepared another substance, in humoral lipoid fraction eluted with 250 mM NaCl, for preventing the death. Mouse given various stresses may differently prepare these adaptogenic humoral lipoids. Depression closely relates to serotonergic and adrenergic neuronal activities. Production of the adaptogenic lipoids may be affected by antidepressants. Cerebrosides are lipoids primarily contented in brain sensing stresses. Cerebrosides may have adaptgenic activity same to the humoral lipoids. Mice were twice given immunization stress, given forced swimming stress or given fear stress on a raised platform, or not given the stresses as a control. Mice were also treated with a serotonin reuptake inhibitor clomipramine or a noradrenaline reuptake inhibitor maprotiline. A humoral lipoid preventing the death was produced in the fraction eluted with 100 mM NaCl of mice given the immunization stress, of mice given the forced swimming stress, or of mice treated with clomipramine or maprotiline. Another humoral lipoid preventing the death was deduced in the fraction eluted with 250 mM NaCl of mice given the immunization stress or of mice treated with maprotiline. Porcine brain cerebroside sulfates, fractionated with 100 mM NaCl and with 250 mM NaCl, dose-dependently prevented the death. These suggest that the adaptogenic humoral lipoids were cerebroside sulfates prepared via serotonergic and adrenergic neuronal activities, corresponding to quality of the stresses.