学術雑誌論文 NON-INVASIVE METHOD FOR PREDICTING HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATIC DISEASE BY MEASURING THE SHEAR WAVE VELOCITY

FUJIWARA, Junichi  ,  GOTO, Takashi  ,  SHIBUYA, Tomomi  ,  CHIBA, Mitsuru  ,  OHSHIMA, Shigetoshi  ,  MIURA, Kouichi  ,  SATO, Wataru  ,  DOHMEN, Takahiro  ,  SAKAI, Toshitaka  ,  SUGIMOTO, Yuko  ,  MINAMI, Shinichiro  ,  OHNISHI, Hirohide

43 ( 1 )  , pp.39 - 49 , 2016-06-30 , 秋田医学会
ISSN:03866106
NII書誌ID(NCID):AN00009294
内容記述
Aim : To evaluate the usefulness of acoustic radiation force impulse (ARFI) in predicting hepatocellularcarcinoma (HCC) in patients with chronic hepatic disease (CHD).Methods : A total of 230 patients participated in this study. They were subsequently classifiedinto the “HCC group” and the “non-HCC group”. We measured their liver stiffness and calculatedthe mean shear wave velocity (SWV) using ARFI.Results : The mean SWV was significantly higher in the HCC group than in the non-HCCgroup. The cut-off value for the mean SWV with the best discrimination between the two groupswas 1.36 (m/s). The area under the receiver operating characteristic curve (AUROC) was0.807. The AUROCs of the aspartate-aminotransferase-to-platelet ratio and Fibrosis 4 scorewere 0.780, 0.728, respectively. The independent risk factors of HCC included the mean SWVand age. A further analysis, based on the individual causes of CHD, found that among the HCVand non-HBV and non-HCV (nBnC) cases, the mean SWV was significantly higher in the HCCgroup than in the non-HCC group.Conclusion : Measuring the SWV using ARFI was a reliable method for predicting HCC in CHDpatients, especially in HCV and nBnC patients.
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http://air.lib.akita-u.ac.jp/dspace/bitstream/10295/3146/1/akitai43-1%2839%29.pdf

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