A HUMORAL LIPID INDUCING STRESS-COPING BEHAVIOR MOTIONLESSNESS ON MOUSE GIVEN FORCED SWIMMING STRESSA HUMORAL LIPID INDUCING STRESS-COPING BEHAVIOR MOTIONLESSNESS ON MOUSE GIVEN FORCED SWIMMING STRESSAN00009294
Forced swimming in narrow space gives mice mental and physical stress. Their stress-copingbehavior is recognized as hyperactivity climbing for escaping from the stressful situation, ormotionlessness for keeping their physical strength. Mice given the stress would produce adaptogenicsubstances inducing the stress-coping behaviors. In the present study, conditions inducingmotionlessness and humoral lipid inducing the behavior are investigated. Themotionlessness of 9 weeks-old DDY mouse was increased in proportion to the given stress durationone day before. The motionlessness of mice with different age given the 10 minutes-stressone day before was increased corresponding to the age. Injection of lipid-fraction eluted with100 mM NaCl obtained from sera of 9 weeks-old mice given the 15 minutes-stress increasedmotionlessness of mice without the previous stress. Fraction eluted with 100 mM NaCl of cerebrosidesulfates also increased the motionlessness with a dose-dependent manner. These suggestthat the humoral lipid with adaptogenic activity might be a cerebroside sulfate.