Journal Article Alterations in Intestinal Permeability Cause Colonic Inflammation and Fibrosis in Type III Phosphatidylinositol Phosphate Kinase-Deficient Mice

NAKAMURA, Ryotaro  ,  TAKASUGA, Shunsuke  ,  HORIE, Yasuo  ,  SASAKI, Takehiko

41 ( 3/4 )  , pp.129 - 135 , 2015-03-31 , 秋田医学会
We recently established mice lacking the type III phosphatidylinositol phosphate kinase gene(PipkIII) in enterocytes, which represent a unique model of intestinal inflammation associatedwith extensive fibrosis that closely resembles human Crohn’s disease. These mutant micedevelop spontaneous juvenile colitis with marked inflammatory cytokine expression, but the primarypathogenic mechanism remains unclear. In the present study, we found that administrationof broad-specific antibiotics effectively ameliorated the colitis of PipkIII-deficient mice, suggestingthe involvement of intestinal bacterial flora in the onset of colitis. Furthermore, we showedthat altered intestinal permeability facilitating commensal bacteria entry putatively caused theintestinal inflammation and fibrosis observed in these mutant mice.

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