Conference Paper 3D Particle Simulation of Liver Cell Proliferation with Angiogenesis - Partial Hepatic Lobule Formation-

Tanaka, Hiroto  ,  Nagayama, Katsuya  ,  Shirakigawa, Nana  ,  Ijima, Hiroyuki

6p.BME005 , 2015-12-18 , Department of Mechanical Engineering, Mahidol University
Recently, the prevalence of viral hepatitis patients has been increasing. Therefore, the reconstruction of liver based on tissue engineering has attracted significant attention. However, the formation or regeneration mechanisms of the liver have not been elucidated; therefore, practical regenerative medicine technology based on tissue engineered liver has not been accomplished. In this study, we propose an analysis model using a Particle Model as the first step. The analysis object is a hepatic lobule. The purpose of this analysis is to elucidate the process of cell proliferation, mechanisms, and states at the micro scale. We used parameters which were obtained by experiments using rats relating to diffusivity, oxygen concentration, and oxygen consumption of a cell. Moreover, we used complex velocity potential of fluid dynamics and obtained a result corresponding to a real hepatic lobule, qualitatively.

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