Conference Paper Particle Simulation on Epidermal Skin Formation - Mechanism of Basal Layer Formation -

Kurihara, Takeshi  ,  Nagayama, Katsuya

6p.BME009 , 2015-12-18 , Department of Mechanical Engineering, Mahidol University
Skin is the largest organ of the human body. The bottom of the epidermis is called the basal layer and is very uneven. However, the mechanism of uneven formation of the basal layer has not yet been elucidated. Computational simulation can be useful in further understanding the mechanisms of skin formation. We propose a particle model that can handle complex biological phenomena, including cell interactions and is a suitable method for the simulation of skin formation. In this study, we created a model similar to the actual skin using three-dimensional analysis and elucidated the formation mechanism of the basal layer. Particularly, each basal cell of this model is subjected to three patterns of cell division, which can simulate skin formation with an increase and decrease of basal cells and the consequent generation of upper cell layers. Therefore, we analyzed the association between these cell division patterns and the uneven formation of the cell layer.

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