学術雑誌論文 Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Nitro-Aldol Reaction of Nitromethane with Isatins

CHENNAPURAM, Madhu  ,  UMMAREDDY , Venkata Subba Reddy  ,  SEKI , Chigusa  ,  OKUYAMA, Yuko  ,  KWON, Eunsang  ,  UWAI, Koji  ,  TOKIWA, Michio  ,  Takeshita, Mitsuhiro  ,  NAKANO, Hiroto

(12)  , pp.1638 - 1646 , 2017-03-27 , Wiley
ISSN:1434-193x1099-0690
NII書誌ID(NCID):AA1118165X
内容記述
A series of new hybrid type squaramide-fused amino alcohol (SFAA) catalysts were synthesized and their catalytic efficiency in enantioselective nitro-aldol reaction of various isatins with nitromethane that afford the chiral 3-substituted 3-hydroxyoxindoles in excellent chemical yields (up to 99%) and high enantioselectivities (up to 95% ee) is described. The resulting chiral 3-hydroxyoxindoles could be used as synthetic precursors for the synthesis of several natural products with a broad spectrum of fascinating biological activities.
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