学術雑誌論文 MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus

Vacca, Barbara  ,  Sanchez-Heras, Elena  ,  Steed, Emily  ,  Balda, Maria S  ,  Ohnuma, Shin-Ichi  ,  Sasai, Noriaki  ,  Mayor, Roberto  ,  Matter, Karl

2016-11-15 , The Company of Biologists
ISSN:2046-6390
内容記述
Ocular morphogenesis requires several signalling pathways controlling the expression of transcription factors and cell-cycle regulators. However, despite a well-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here, we identify a requirement for MarvelD3, a tight junction transmembrane protein, in eye morphogenesis in Xenopus. MarvelD3 depletion led to an abnormally pigmented eye or even an eye-less phenotype, which was rescued by ectopic MarvelD3 expression. Altering MarvelD3 expression led to deregulated expression of cell-cycle regulators and transcription factors required for eye development. The eye phenotype was rescued by increased c-Jun terminal Kinase activation. Thus, MarvelD3 links tight junctions and modulation of the JNK pathway to eye morphogenesis.
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http://bio.biologists.org/content/5/11/1631.abstract

http://library.naist.jp/dspace/xmlui/bitstream/10061/11753/1/1631.full.pdf

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