Departmental Bulletin Paper 限外濾過膜の透過性能に及ぼす流量条件の影響

今井, 醇

Currently in Japan more than 340,000 patients with end-stage kidney disease (ESKD) receive blood purification therapy, and the number of patients is increasing year by year. Hemodialysis utilizing diffusive mass transfer due to the concentration gradient is commonly used for ESKD patients; however, use of ultrafiltration is more effective for removing much larger solutes with higher toxicity. The treatment of this kind is called Hemofiltration or apheresis, depending on the target molecules. Transport of water across the membraneaccompanies solutes; however, the rate is not necessarily equal to that of water. In this study, ultrafiltration experiments were performed with an ultrafiltration membrane for various solutes. We have concluded that the concentration polarization effect plays a significant role for solute transport especially for larger solutes. It is also proved that lower wall shear rate that should develop a tight concentration polarization may enhance the rate of transport for larger solutes, which turns important in clinical situation.Key Words : ultrafiltration, Concentration polarization, Wall shear rate

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