Departmental Bulletin Paper 心電図 QT-RR 間隔共変性を用いた2 型糖尿病患者の重症度評価

増田, 裕太

57pp.1 - 6 , 2016-03-24 , 法政大学大学院 理工学研究科
This paper proposes a method for the stratification of type 2 diabetic patients. The mutual entropy between RR and QT intervals over 24 hour Holter ECG recordings as a measure of QT-RR co-variability has been adopted for the stratification among diabetic, high blood pressure patients and control. Then additional diabetic related indices such as BMI, TC, TG, Cr, SBP are integrated to see if patients with major adverse cardiovascular events (MASE) are differentiated among all diabetic patients. Data were obtained from 19 diabetic patients, 9 high blood pressure patients and 24 control subjects. Mutual entropy between beat to beat QT and RR intervals showed a good stratification result between control and combined class of diabetic and high blood pressure patients. High blood pressure patients showed less QT-RR co-variability but was not statistically significant. Logistic regression analysis revealed that the set of indices, the mutual entropy, Cr and SBP showed best separation of MACE with sensitivity 0.80 and specificity 0.923. Although the number of data is limited, the results show the method would be useful for the stratification of diabetic patients. Keywords : diabetes, Holter ECG, QT intervals, RR intervals, QT-RR co-variability, biosignal classification, mutual entropy,

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