Research Paper ポジトロン断層法脳血流計測を用いた運動負荷時の脳循環調節機構の解明

日浦, 幹夫

pp.1 - 4 , 2015-06-16
研究成果の概要(和文):陽電子放出断層撮像法(positron emission tomography ; PET)を用いて健常若年男性を対象として低強度の自転車エルゴメーター運動負荷前後での局所脳血流量(regional cerebral blood flow ; rCBF)を解析した結果、1)運動開始時と継続時ではrCBF変化のパターンが異なり、下肢の筋群からの上行性神経伝達、central commandなどが運動中の脳循環調節に関与することを提示した。2)運動後は後部帯状回等において約16%のrCBF減少を認めた。3)同じ条件の運動における前頭葉皮質の局所脳酸素代謝の変化はrCBFとは異なることが確認された。研究成果の概要(英文):We investigated changes in regional cerebral blood flow (rCBF) during cycling ergometer which was continued at low intensity. Main findings of this research project are; 1) Distribution of increased rCBF during exercise was differed between the onset and a later phase of exercise. Afferent neural impulse from working muscles in lower limbs and central command would have a role in regulation of rCBF during exercise. 2) rCBF reduced after exercise secession by 16 %, approximately, in several regions such as posterior cingulate gyrus. 3) The similar type of exercise as evaluated in the PET study induced changes in regional oxygennation which were distinct from the tendency of those in rCBF.

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