紀要論文 宿主体内生存戦略のための大腸菌ゲノム制御ネットワークの研究
STUDIES ON THE GENOME REGULATORY NETWORK FOR SURVIVAL WITHIN HOST ANIMALS IN ESCHERICHIA COLI

山中, 幸  ,  YAMANAKA, Yuki

(56) 2015-03-24 , 法政大学大学院理工学・工学研究科
ISSN:2187-9923
NII書誌ID(NCID):AA12677220
内容記述
During colonization of the gastrointestinal tract, enterobacteria construct a hierarchic regulatory network of genome expression to adapt to environmental stresses. My studies revealed novel cascade regulations by YdeO and GadE, which are transcriptional factors known to control the glutamate-dependent acid resistance system in Escherichia coli. YdeO forms the characterized two transcriptional cascades, YdeO > YiiS > CadC and YdeO > GadE for controlling two acid resistance systems, which are dependent on glutamate and lysine. Moreover, GadE induced by YdeO forms other regulatory cascades, GadE > HdeD > LrhA > FlhDC and GadE > HdeD > GadX. Taking all the results together, my thesis presents a hierarchic multi-regulatory network followed by acid resistance factors to achieve colonization in a large intestine within host animals.
本文を読む

http://repo.lib.hosei.ac.jp/bitstream/10114/11034/1/12R9701%e5%b1%b1%e4%b8%ad%e5%b9%b8.pdf

このアイテムのアクセス数:  回

その他の情報