Departmental Bulletin Paper ビフィズス菌との相互作用で誘導される大腸菌遺伝子の同定と発現制御

小島, 渓晃

562015-03-24 , 法政大学大学院理工学・工学研究科
Quorum sensing (QS) is a bacterial cell-cell communication process by which bacteria communicate using extracellular signals called autoinducers. Escherichia coli and Bifidobacterium longum are member of the normal microflora of human intestine. In this study, we characterize novel QS between E. coli and B. longum. Transcriptome analysies showed that condition medium from B. longum culture (BLCM) induced more than 125genesof E. coli, including uhpT gene. Northern blotting and reporter analyses confirmed that signal(s) in BLCM, which is stable at between 37oCto 25oC,induceduhpT promoter in the dependent manner of UhpAB two-component system.

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