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全身性アミロイドーシス検索薬125I-EISBの研究 : 最適反応時間および安定性の検討全身性アミロイドーシス検索薬125I-EISBの研究 : 最適反応時間および安定性の検討AA12010572
ゼンシン セイ アミロイドーシス ケンサク ヤク 125I-EISB ノ ケンキュウ : サイテキ ハンノウ ジカン オヨビ アンテイ セイ ノ ケントウ
Study of 125I-EISB for Detecting Systematic Amyloidosis : Evaluation for optimal synthesis time and stability of 125I-EISB |
"/柏, 昂希/"柏, 昂希 ,
"/副島, 彩花/"副島, 彩花 ,
"/松永, 浩文/"松永, 浩文 ,
"/山下, 太郎/"山下, 太郎 ,
"/冨吉, 勝美/"冨吉, 勝美 ,
"/カシワ, コウキ/"カシワ, コウキ ,
"/ソエジマ, アヤカ/"ソエジマ, アヤカ ,
"/マツナガ, ヒロフミ/"マツナガ, ヒロフミ ,
"/ヤマシタ, タロウ/"ヤマシタ, タロウ ,
"/トミヨシ, カツミ/"トミヨシ, カツミ ,
"/Kashiwa, Koki/"Kashiwa, Koki ,
"/Soejima, Ayaka/"Soejima, Ayaka ,
"/Matsunaga, Yoshifumi/"Matsunaga, Yoshifumi ,
"/Yamashita, Taro/"Yamashita, Taro ,
"/Tomiyoshi, Katsumi/"Tomiyoshi, Katsumi
14pp.42
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47 , 2018-03-31 , 熊本大学
NCID:AA12010572
Description
1-(2-mestyl-ethoxy) -2,5bis (styryl) benzene (EMSB) is newly synthesized and reacted with 125I with Kripffix222 to obtain 1- (125I-ethoxy) -2,5bis (styryl) benzene (125I-EISB) which is a new amyloid imaging probe that canimage amyloid by Single Photon Emission Computed Tomography (SPECT). The purpose of study is to determine the optimal synthesis time and clarify stability of 125I-EISB in saline and human serum, respectively. We synthesized 125I-EISB and injected 125I-EISB into saline and human serum. We used high performance liquid chromatography (HPLC) toacquire radiochemical purity of 125I-EISB. We assess changes of radiochemical purity of 125I-EISB over time. As a result, high radioactive purity 95.88±3.19% was obtained in 10 minutes by our synthesis and the radiochemical purity was 97.83±1.40% (n=6) applying our purification system. Radiochemical purity 24 hours later was 94.01±2.09% after injecting in saline. That was 94.23±1.20% after injecting in human serum. From these results, optimal synthesis time was determined 10 minutes and radiochemical purity of 125I-EISB was stably maintained in saline and human serum,respectively.
Full-Text
http://reposit.lib.kumamoto-u.ac.jp/bitstream/2298/39288/1/MH0014_042-047.pdf
