Journal Article Functionalization of a Pyridine Framework through Intramolecular Reissert-Henze Reaction of N-(Carbamoyloxy)pyridinium Salts and Unexpected Insertion of Ethereal Solvents

Asahara, Haruyasu  ,  Kataoka, Asuka  ,  Hirao, Shotaro  ,  Nishiwaki, Nagatoshi

2015 ( 18 )  , pp.3994 - 3999 , 2015-06 , WILEY-VCH Verlag GmbH
ISSN:1099-0690
Description
A new strategy for synthesis of the 2-pyridyl carbamates is reported. This strategy exploits a new intramolecular transformation of an acyloxy group from N-carbamoyloxypyridinium salts (Reissert-Henze-type reaction) as the key step. Addition of a silver salt effectively accelerates the intramolecular attack of the carbonyl oxygen at the 2-position of the pyridine ring. Additionally, a new rearrangement of the acyloxy group, combined with insertion of an ethereal solvent to give pyridine derivatives having a coordinating tether, is reported.
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