紀要論文 The bone regeneration using bone marrow-derived mesenchymal stem cell with recombinant human bone morphogenetic protein-2 in allogeneic repair model of femoral segmental defect of rats
ラット大腿骨部分欠損モデルを用いたrecombinant human bone morphogenetic protein-2 併用同種骨髄幹細胞移植による骨形成能に関する研究
The bone regeneration using bone marrow-derived mesenchymal stem cell with recombinant human bone morphogenetic protein-2 in allogeneic repair model of femoral segmental defect of rats

高野, 満夫  ,  橋本, 淳一  ,  土田, 浩之  ,  高木, 理彰

内容記述
 Treatment of a large bone defect is a difficult problem especially in modern aging society.Mesenchymal stem cells (MSCs) obtained from bone marrow are a suitable resource for bone regeneration. We performed a transplant of MSCs along with recombinant human bone morphogenetic protein 2 (rhBMP-2) in combination with an allogeneic bone marrow stem cell transplant in a rat model of a femoral segmental defect and observed sufficient bone formation. A single dose or 2-week administration of an immunosuppressive drug was necessary to ensure successful bone formation by the allogeneic stem cell transplant. Equivalent bone formation was attained in all groups 6 weeks after the transplant. As for the persistent administration of the immunosuppressive drug, it was found to be unnecessary because almost all transplanted allogeneic stem cells were absorbed during 8 weeks after the transplant.
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