紀要論文 Genotoxicity of occupational exposure of anesthesiologists to sevoflurane : The relationship between DNA damage and the work environment
麻酔科医におけるセボフルラン慢性曝露による遺伝毒性影響
Genotoxicity of occupational exposure of anesthesiologists to sevoflurane : The relationship between DNA damage and the work environment

大瀧, 恵  ,  川前, 金幸  ,  石川, 恵生  ,  小田, 真也

内容記述
Background: Inhalation anesthetics are often used for general anesthesia. However, several studies have reported that occupational exposure to inhalation anesthetics induces DNA damage and that sevoflurane anesthesia causes reversible genotoxic effects in patients. Our aim was to investigate the genotoxic effects in anesthesiologists of occupational exposure to sevoflurane, and to reveal the relevance of DNA damage and the work environment of anesthesiologists.Methods: Alkaline comet assay of the peripheral blood lymphocytes of 53 anesthesiologists (exposed group) and 37 office workers (control group) was performed, following which 100 cells were classified into 5 classes: 0: no migration, to 4: very high migration, the distance of migration being dependent on the degree of DNA damage. The total comet score (TCS) was calculated as n1+2×n2+3×n3+4×n4. Anesthesiologists were asked about their work environment.Results and Conclusions: TCSs were no different between the exposed and control groups (7.16±7.88 vs. 7.63±6.73, p=0.82) (95%CI 3.91-10.41 vs. 4.97-10.29). There was no significant association between TCS and the frequency of usage of sevoflurane. In conclusion, our study did not reveal DNA damage with chronic occupational exposure to sevoflurane.
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