Departmental Bulletin Paper ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma
ZEB-1およびE-cadherin発現は浸潤性乳管癌の再発予測因子となり得る
ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma

柴田, 健一  ,  鈴木, 明彦  ,  渡邊, 利広  ,  高須, 直樹  ,  平井, 一郎  ,  木村, 理

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Background: Epithelial-Mesenchymal Transition (EMT) plays an important role in cancer progression and metastasis. We investigated the expression of two EMT-related molecules, ZEB-1 and E-cadherin, in invasive ductal breast carcinoma and evaluated their association with clinicopathological parameters and recurrence-free survival.Methods: We evaluated the expression of ZEB-1 and E-cadherin in 116 patients of Stage I, II, and III primary invasive ductal breast carcinoma (mean age, 58.5 years, male: female = 0:116) using immunohistochemistry.Results: Of the 116 patients, 51 (44%) had Stage I, 58 (50%) had Stage II, and 7 (6%) had Stage III tumors. Thirty seven patients (32%) had lymph node metastasis. One hundred and one patients (87%) had ER positive tumors, and 20 patients (17%) had HER2 positive tumors. Positive ZEB-1 expression was observed in the tumors of 66 patients (57%), but it was not significantly associated with clinicopathological parameters. Reduced E-cadherin expression was observed in the tumors of 34 patients (29%). It was significantly associated with negative estrogen receptor expression. Patients with a positive ZEB-1 and / or reduced E-cadherin had a poorer outcome than the other patients in terms of recurrence-free survival.Conclusion: ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma.
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