学術雑誌論文 Multifocal human papillomavirus detection in palatine and pharyngeal tonsils

Murono, Shigeyuki  ,  Yoshida, Hiroshi  ,  Kobayashi, Tetsuro  ,  Kawase, Tomotaka  ,  Kikuchi, Daisuke  ,  Suzuki, Toshihiko  ,  Nakanishi, Yosuke  ,  Endo, Kazuhira  ,  Kimura, Hiroaki  ,  Wakisaka, Naohiro  ,  Yoshizaki, Tomokazu

138 ( 5 )  , pp.483 - 486 , 2018-05-04 , Taylor and Francis Ltd
ISSN:0001-6489
NII書誌ID(NCID):AA0050923X
内容記述
金沢大学医薬保健研究域医学系
Background: Multifocal human papillomavirus (HPV) infection into the palatine and pharyngeal tonsils, which might be linked to a second primary tumor of HPV-positive oropharyngeal cancer (OPC), was investigated. Patients and methods: One hundred and five patients with various head and neck diseases including 14 patients with OPC were enrolled in this study. Swabs from the palatine and pharyngeal tonsils were collected in each individual, and auto-nested GP5+/GP6+ PCR for HPV DNA was performed. Results: HPV DNA was detected in the palatine tonsil or the pharyngeal tonsil in a small subset of upper respiratory tract cancer other than OPC (URTC) and non-cancer diseases. Furthermore, HPV DNA was detected in both the palatine and pharyngeal tonsils in the same individual in 2 of 48 (4%) URTC cases, and 1 of 43 (2%) non-cancer cases. On the other hand, p16-positive OPC cases demonstrated a higher HPV DNA detection rate (4 of 9, 44.4%) compared with other disease groups. Conclusion: HPV DNA detection in both the palatine and pharyngeal tonsils in the same individual, especially in HPV-OPC, suggested the ability of HPV to infect tonsillar tissues of Waldeyer’s ring multifocally. © 2017 Acta Oto-Laryngologica AB (Ltd)
Embargo Period 12 months
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