学術雑誌論文 Nucleophilic substitution reactions on indole nucleus: Formation of (3a,8a-cis)-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indoles having a substituent at the 3a-position

Yamada, Fumio  ,  Goto, Aya  ,  Hasegawa, Masakazu  ,  Kobayashi, Kensuke  ,  Somei, Masanori

95 ( 2 )  , pp.844 - 861 , 2017-12-13 , Japan Institute of Heterocyclic Chemistry
ISSN:0385-5414
NII書誌ID(NCID):AA00663739
内容記述
金沢大学医薬保健研究域薬学系
Various nucleophiles, such as indole, 1,2,3-trimethoxybenzene, anisole, phenol, and pyrrole, reacted with 1-hydroxy-Nb-trifluoroacetyltryptamine under the presence of mesyl chloride to give novel series of (3a,8acis)- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles having a substituent at the 3aposition. Their structures and by-products were strictly determined. © 2017 The Japan Institute of Heterocyclic Chemistry.
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