学術雑誌論文 Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells

Ikuta, Naoko  ,  Chikamoto, Keita  ,  Asano, Yuya  ,  Yasui, Yoshiaki  ,  Yokokawa, Haruka  ,  Terao, Keiji  ,  Rimbach, Gerald  ,  Matsugo, Seiichi

20 ( 3 )  , pp.211 - 222 , 2017-03-01 , Mary Ann Liebert Inc.
ISSN:1096-620x
NII書誌ID(NCID):AA11517488
内容記述
Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(-)-LA (S-LA). Of these, R-LA is naturally occurring and an essential cofactor in energy metabolism. R-LA treatment has been reported to affect glucose metabolism in rat hepatoma cells. This study analyzed the time course of metabolite levels in LA-treated cultured H4IIEC3 rat hepatoma cells, including a specific evaluation of the effect of R-LA and the enantioselectivity of LA. Principal component analysis showed that this experiment was well designed to observe enantioselectivity. R-LA treatment was found to inhibit the glycolysis and Thr-Gly-Ser pathways, as well as lactic acid production, leading to the inhibition of gluconeogenesis in starved H4IIEC3 cells. This study may provide mechanistic insight into how R-LA induces apoptosis in hepatoma cells. © Copyright 2017, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2017.
Embargo Period 12 months
本文を読む

https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=10852&item_no=1&attribute_id=26&file_no=1

このアイテムのアクセス数:  回

その他の情報