Journal Article ラットヒラメ筋に対する廃用性筋萎縮予防としての間歇的伸張運動の効果: 介入時間と筋の長軸部位間における相違の検討
Inhibitory Effect of Different Durations of Intermittent Stretching on Muscle Disuse Atrophy in Different Regions of the Rat Soleus Muscle

木村, 繁文  ,  石川, 琢麻  ,  山崎, 俊明

32 ( 2 )  , pp.291 - 296 , 2017-01-01 , Society of Physical Therapy Science = 理学療法科学学会
〔目的〕ラットヒラメ筋の廃用性萎縮進行中の間歇的伸張運動の効果を時間別,部位別に検討することとした.〔対象と方法〕8週齡のWistar系雄ラットの両側ヒラメ筋を対象に,これを通常飼育群,16日間の後肢懸垂にて廃用性筋萎縮を惹起するH群,実験期間中に間歇的伸張運動を5分間実施するSST群,10分間実施するLST群に分けた.部位は筋長の25%を近位部,50%を中央部,75%を遠位部とし,検討項目は各群と部位の筋線維横断面積,壊死線維,中心核線維の発生頻度とした.〔結果〕筋横断面積は遠位部においてLST,SST群ではH群と比較し,また中央部,遠位部においてSST群ではLST群と比較し有意に大きかった.〔結語〕短時間の伸張運動では伸張部位や時間によって廃用性筋萎縮の抑制効果が異なることが示唆される. [Purpose] The purpose of this study was to verify the influence of the time duration of intermittent stretching on the inhibitory effects of disuse atrophy in the rat soleus muscle and to compare these effects across different sites along its longitudinal axis. [Subjects and Methods] Thirty 8-week-old male Wistar rats were divided into 4 experimental groups: control, hind-limb suspension (H), hind-limb suspension and stretching for 10 minutes every day (LST), and hind-limb suspension and stretching for 5 minutes every day (SST). At the end of the suspension period, the soleus muscle was excised and cut into proximal, middle, and distal samples, and the cross-sectional area (CSA) was measured. [Results] The cross-sectional area of muscle fibers was significantly higher in the LST and SST groups than in the H group in the middle and distal regions, and it was also higher in the SST group than in the LST group in the distal region. [Conclusion] These results suggest that the effect of intermittent stretching differs among the longitudinal sites of the rat soleus muscle, and depends on the duration of the stretching time.

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