Journal Article Evaluation of the effects of gastrectomy on the development of metabolic bone disease

Higashi, Yuki  ,  Fujimura, Takashi  ,  Oyama, Katsunobu  ,  Kinoshita, Jun  ,  Miyashita, Tomoharu  ,  Tajima, Hidehiro  ,  Fushida, Sachio  ,  Ohta, Tetsuo

212pp.1 - 7 , 2017-05-15 , Academic Press Inc. / Elsevier
ISSN:0022-4804
Description
Background Metabolic bone disease after gastrectomy is one of the complications leading to deterioration in quality of life. The exact mechanism of the metabolic bone disease remains unclear. To clarify the cause of metabolic bone disease after gastrectomy, we evaluated the associations between the method of gastrectomy and the development of metabolic bone disease in a rat model. Methods Rats were assigned to four groups as follows: (1) sham operation (control group); (2) resection of the glandular stomach with Billroth I reconstruction (RGBI group); (3) Roux-en-Y anastomosis preserving the secretory function of the whole stomach (PSRY group); and (4) total gastrectomy with Roux-en-Y reconstruction (TGRY group). In all groups, body weight, serum biochemistry (total protein, albumin, calcium, phosphorus, tartrate-resistant acid phosphatase, and bone alkaline phosphatase), bone density, and bone breaking strength were measured. Results Body weights and serum calcium levels were significantly lower in the three operation groups compared with the control group. Bone density was significantly lower in the PSRY and TGRY groups compared with the control group. Bone breaking strength was significantly lower in the three operation groups compared with the control group. Conclusions Surgical methods led to metabolic bone disease. However, exclusion of the duodenum from food passage had major influence to reduction in bone density and breaking strength. A stomach-preserving procedure and physiological reconstruction which enable food passage through duodenum and proximal jejunum contribute to mitigation of metabolic bone disease. © 2016 Elsevier Inc.
Full-Text

http://dspace.lib.kanazawa-u.ac.jp/dspace/bitstream/2297/47083/1/HO-PR-OYAMA-K-1-7.pdf

Number of accesses :  

Other information