||Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C–O Axially Chiral Enolates
Tomohara, Keisuke ,
Kasamatsu, Koji Yoshimura, Tomoyuki ,
Furuta, TakumiKawabata, Takeo
Chemical and Pharmaceutical Bulletin
906 , 2016 , 日本薬学会 = The Pharmaceutical Society of Japan
Enantioselective intramolecular conjugate addition reactions of short-lived C–O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).