学術雑誌論文 Isolation and characterization of hematopoietic stem cells in teleost fish

Kobayashi, Isao  ,  Katakura, Fumihiko  ,  Moritomo, Tadaaki

58pp.86 - 94 , 2016-05-01 , Elsevier Ltd
ISSN:0145-305X
NII書誌ID(NCID):AA00627870
内容記述
Despite 400 million years of evolutionary divergence, hematopoiesis is highly conserved between mammals and teleost fish. All types of mature blood cells including the erythroid, myeloid, and lymphoid lineages show a high degree of similarity to their mammalian counterparts at the morphological and molecular level. Hematopoietic stem cells (HSCs) are cells that are capable of self-renewal and differentiating into all hematopoietic lineages over the lifetime of an organism. The study of HSCs has been facilitated through bone marrow transplantation experiments developed in the mouse model. In the last decade, the zebrafish and clonal ginbuna carp (Carassius auratus langsdorfii) have emerged as new models for the study of HSCs. This review highlights the recent progress and future prospects of studying HSCs in teleost fish. Transplantation assays using these teleost models have demonstrated the presence of HSCs in the kidney, which is the major hematopoietic organ in teleost fish. Moreover, it is possible to purify HSCs from the kidney utilizing fluorescent dyes or transgenic animals. These teleost models will provide novel insights into the universal mechanisms of HSC maintenance, homeostasis, and differentiation among vertebrates. © 2016.
本文を読む

http://dspace.lib.kanazawa-u.ac.jp/dspace/bitstream/2297/45523/1/SC-PR-KOBAYASHI-I-86.pdf

このアイテムのアクセス数:  回

その他の情報